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Dharan, Shaiju S.
- Peroxisome Proliferator-Activated Receptors (PPARs) -A Review
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1 Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Thiruvananthapuram, Kerala, IN
1 Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Thiruvananthapuram, Kerala, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 4, No 1 (2014), Pagination: 32-37Abstract
PPARs are ligand-activated transcription factors involved in the transcriptional regulation of key metabolic pathways such as lipid metabolism, adipogenesis, and insulin sensitivity. More recent work implicates all 3 PPAR isotypes (α, γ, and δ) in inflammatory and atherosclerotic pathways. Because these nuclear receptors are activated by extracellular signals and control multiple gene targets, PPARs can be seen as nodes that control multiple inputs and outputs involved in energy balance, providing insight into how metabolism and the vasculature may be integrated. The ongoing clinical use of synthetic PPAR agonists, eg, insulin-sensitizing thiazolidinediones (TZDs) and lipid-lowering fibrates, and the evidence that PPAR activation also may limit inflammation and atherosclerosis have only heightened this interest and the pursuit of novel PPAR agonists. Together, these various observations have stimulated intense interest in PPARs as therapeutic targets and led to large-scale cardiovascular end-point trials with PPAR agonists.References
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- Lefebvre AM, Chen I, Desreumaux P, Najib J, Fruchart JC, Geboes K, Briggs M, Heyman R, Auwerx J 1998 Activation of the peroxisome proliferator-activated receptor g promotes the development of colon tumors in C57BL/6J-APCMin/1 mice. Nat Med 4:1053-1057
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- Ito Y, Azrolan N, O’Connell A, Walsh A, Breslow JL 1990 Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice. Science 249:790-793
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- Neuropeptides-A Review
Abstract Views :151 |
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Affiliations
1 Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Thiruvananthapuram, Kerala, IN
1 Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Thiruvananthapuram, Kerala, IN
Source
Asian Journal of Pharmaceutical Research, Vol 4, No 4 (2014), Pagination: 198-200Abstract
Neuropeptides are peptidergic neurotransmitters, which are produced by neurons. Most neuropeptides where initially discovered in the brain, but later it became clear that a large number of these peptides is also present in secretory vesicles of unmylinated sensory nerve endings of the enteric nervous system. Neuropeptides in enteric nervous system include calcitonin gene-related peptide, vasoactive intestinal polypeptide, somatostatin and substance P, gatrin releasing peptide, neurotensin, motiline and galanin. Many of these peptides are also found in enterocytes in the mucosa. These neuropeptides are released from the enterocytes as a paracrine or endocrine substance under the influence enteric nervous system.- Anxiety Disorders–A Review
Abstract Views :546 |
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Authors
Affiliations
1 Department of Pharmacology, Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Thiruvananthapuram, Kerala., IN
1 Department of Pharmacology, Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Thiruvananthapuram, Kerala., IN
Source
Asian Journal of Pharmaceutical Research, Vol 7, No 4 (2017), Pagination: 217-221Abstract
Anxiety is defined as the state of fear, apprehension, tension, panic and restlessness. If the symptoms of anxiety interfers the daily life activities then these are called anxiety disorders. Nowadays, anxiety became an important symptom of various mental disorders such as major depressive disorders, obsessive compulsive disorders, panic disorders, post traumatic stress disorders and various phobias. These disorders mainly affects one-eighth of the total population worldwide and became an important area in the psychopharmacology. The management of anxiety disorders results in high expenditure and negative impact on quality of life. Currently allopathic drugs became the major scenario in the anxiety treatments but these treatments produce large amounts of adverse effects. Use of herbal remedies for the treatment of anxiety is in fast progress. The phytoconstituents of these medicinal plants are found to be acting through the serotonin and GABA neurotransmitters.Keywords
Anxiety, Fear, Seratonin, GABA, Panic, Obsessive Compulsive Disorders, Herbal Remedies.References
- Steven LS. Recent Advances in the Understanding and Treatment of Anxiety Disorders. Prim Care Clin Office Pract. 2007; 34: 475–504.
- Christopher G, Oliver D. Generalized anxiety disorder .BMJ 2007:334:579-81.
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- Mohale DS. Neurobiological modulators of anxiety. International Research Journal of Pharmacy. 2012; 3(1): 60-64.
- Shivani S, Ashwani A. Understanding the Pathophysiology and Management of the Anxiety Disorders. International journal of pharmacy and pharmaceutical research. 2015; 4 (3): 251-278.
- Alexander B, Sahib SK, Michael E. Current Diagnosis and Treatment of Anxiety Disorders. Pharmacy and Therapeutics. 2013; 38 (1): 30-44.
- Frank JF, Larry DP, Janie JJ, Alissa B J. Pharmacological treatment of anxiety disorders: Current treatments and future directions. J Anxiety Disord. 2012; 26(8): 833–843.
- Neeraj G, Dinesh D. A review on Anti anxiety plants. Natural Product Radiance. 2008; 7(5): 476-483.
- Preeti, Milind P, Kailash S. Medicinal plants possessing anxiolytic activity: A brief review. Der Pharmacia Sinica. 2015, 6(5):1-7.
- Ethno Pharmacological uses of Artocarpus altilis– A Review
Abstract Views :523 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacology, Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Thiruvananthapuram, Kerala., IN
1 Department of Pharmacology, Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Thiruvananthapuram, Kerala., IN
Source
Asian Journal of Pharmaceutical Research, Vol 7, No 4 (2017), Pagination: 239-243Abstract
In recent years, medicinal plants play an important role in allopathic medicine, herbal medicine, homoeopathy and aromatherapy, as being the sources of many imperative drugs in the modern world. Use of potent herbal medicines like Breadfruit (Artocarpus altilis) belongs to Moraceae family against various ailments to reduce the adverse effects of various orthodoxallopathic medicines. The detrimental side effects of conventional antibiotics can be easily overcome by the use of these medicinal plants as analternative treatment of diseases by producing a variety of compounds of known therapeutic properties. Many research works are ongoing with Artocarpus altilis and paid more attention to its bioactive constituents for the development of newer medicines in the pharmaceutical field.Keywords
Artocarpus altilis, Antibiotics, Herbal Medicines, Allopathic Medicines, Homoeopathy, Aromatherapy, Bread Fruit.References
- Somashekhar M, Naira N, Basavraj S. A Review on Family Moraceae (Mulberry) With a Focus on Artocarpus Species. World J. Pharm. Pharmaceut. Sc. 2013; 2(5): 2614-2621.
- Jagtap UB, Bapat VA. Artocarpus: A review of its traditional uses, phytochemistry and pharmacology. J. Ethnopharmacol. 2010; 12(9): 143-144.
- Naira N. Artocarpus altilis: Over View of a Plant which is referred to as Bread Fruit. International Journal of Pharmaceutical Sciences Letters. 2013; 3(5): 273-276.
- Monalisa M, and Chinmay PA Review on Phytochemistry, Bio-Efficacy, Medicinal and Ethno-Pharmaceutical Importance of Artocarpus altilis. International Journal of Pharmacy and Pharmaceutical Research.2015; 3 (1): 219-231.
- Mukesh SS, Boey JH, Kumutha S, Bavani DV. A Review on Artocarpus altilis (Parkinson) Fosberg (breadfruit).Journal of Applied Pharmaceutical Science. 2014; 4 (8): 91-97.
- Erwin. Diversity of secondary metabolites of Artocarpus altilis. International conference of chemistry. 2015: 53-65.
- Jones AMP, Ragone D, Tavana NG. Beyond the bounty: Bread fruit (Artocarpus altilis ) for food security and novel foods in the 21st century. Ethanobotany Research and Applications. 2011; 9: 129-1479.
- Sudha S, Asna U. Safety evaluation of Artocarpus altilis as pharmaceutical agents. Journal of Toxicology.2014: 1-8.
- Pradhan C, Mohanty M, Rout APhytochemical screening and comparative bioefficacy assessment of Artocarpus altilis leaf extracts for antimicrobial activity. Frontiers in Life Science.2012 ; 6 (3–4): 71–76.
- Donsing P, Limpeanchob N, Viyoch J. Evaluation of the effect of Thai breadfruit's heartwood extract on melanogenesis-inhibitory and antioxidation activities. J Cosmetic Sci 2008; 59 (1): 41-58.